Season 1

Mark's hands are 20 times bigger than a normal adult male's. After learning that his condition may require amputation, Mark stopped seeing doctors. Now troubling changes to his hands means he must go back. If not for himself, then for his young daughter.

Winner of the Uganda's Ugliest Man contest, Godfrey has a disorder that has left him disfigured.

In Brazil, Claudio lives with a condition that bent his head backward.

In Turkey, the world's tallest woman lives with an unknown condition.

Milagros lives with tumors so heavy that her face droops down to her torso.

Lalit's face and body have been covered in hair since the day he was born.

Mahfuza and Nelly are living with Harlequin ichthyosis.

Summer has macromastia which causes her breasts to keep growing.

Conjoined twins Jose Luis and Jose Armando get advanced medical care.

Dimas' family worries his marial arts training will harm his bendy body.