Overview
All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.
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Ellen Pompeo
Meredith Grey
Chandra Wilson
Miranda Bailey
Sandra Oh
Cristina Yang
Justin Chambers
Alex Karev
James Pickens Jr.
Richard Webber
Patrick Dempsey
Derek Shepherd
Kevin McKidd
Owen Hunt
Katherine Heigl
Izzie Stevens
Sara Ramirez
Callie Torres
Eric Dane
Mark Sloan
Chyler Leigh
Lexie Grey
T. R. Knight
George O'Malley
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